The Substance P Cascade diagram was composed as a quick summary, for doctors and
laypersons, of illnesses that are often seen when there is a cranio-mandibular disorder (i.e. compromised dental orthopedic relationship) leading to systemic elevated sustance P levels. Research has shown that cranio-mandibular dysfunction manifests illness in a chaotic manner (low incidence over a broad spectrum of diseases). Typically, bite dysfunction causes a continuum of disorders over one’s lifetime, morphing from one illness to another as one ages. Collectively, the medical history paints a very vivid picture of causation to those knowledgeable of the substance P cascade.