There is extensive medical research literature on substance P. A search on Pubmed shows over 22000 articles that refer to substance P.
What follows in the Library are a number of articles on specific topics that substantiate the observed connection between a compromised dental orthopedic condition and numerous medical disorders. Even as numerous substance P antagonist (i.e. nk1 receptor antagonist) become available, pharmaceutical management is not the best treatment because the substance P will still be in a patients system causing various other disorders.
Substance P Overview
Substance P effects: